MDMA made me lose all self esteem and depressed?

i'm female, 21. I did ecstasy with my best guy friend.

The first time i tried mdma, it was bliss. I was so confident and outgoing and happy :D

The second time i tried it, exactly the opposite happened to me. During the entire trip i had ZERO self esteem, was paranoid and depressed. WHy did this happen??!

Some factors to consider

-We sniffed md+2% coke and also drank vodka

-I've had like 6 hours of sleep in two days (lack of sleep basically)

-He told me about this incident JUST before we sniffed: Apparently i walked out in a bra and jeans the frst time we sniffed, and his neighbors were laughin at me (because i am so flat-chested) and he felt bad for me. THAT HURT DEEP, i dont even know why

-My mom had called previously and told me not to do wrong things and that she is trusting that i wont.

Could any of the above have been the reason i went into the bad trip? Why did my self esteem disappear??

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