A Dog's Immune System?

Would it ever be possible for a dog to become immune to something that is usually toxic for them, such as chocolate or grapes? I know that chocolate has so many components that it would be too hard to become immune to, but what about grapes? There is one chemical in them that dog's can;t handle, it starts with an x I believe. So if you were to give a dog grapes in smaller to larger doses over time, could they build a tolerance to them?

This is all hypothetical, of course ^.^

Thanks!

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