How do I report a puppy mill?

My husband's acquaintance works at a "dog breeder." My husband went to visit it today, and it is a flat-out, disgusting puppy mill!!! The original owner died, and now her sons have taken over. The dogs NEVER get to go outside. Each day they get their poop and pee sprayed out of their little cage. They breed them every time the females go into heat. Who do we report this to? We would love to see this place get closed down. It's awful what they are doing to these dogs. Any info would help! (The puppy mill is located in the St. Louis, MO area.)

Update:

I am not sure who is giving all the thumbs down! Trolls.

Thanks for everybody's advice. I will call the ASPCA tomorrow!

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