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The packaging for the Depo shot recommends that you do not even try to concieve for 18 months after your last shot. I found that out the hard way. Two miscarriages later they tell me. And that was my first depo shot. I dont know about long term usage. Good luck to you. I agree that your fertility will be individualized.

From what I understand, depo-provera has been blacklisted in some places due to the long term harmful side effect on the reproductive system. Technically you're supposed to wait 18 months to try to conceive, but as long as you've been on it I really would talk to the doctor first, and make sure everything is functioning normally.

some people yes and some people no. I was on depo for 5 yrs the min i got off i was prego. My girlfriend was on depo and pill for 12 could not get prego for 1 year. Her body just could not regulate so it depends on woman. Good Luck in your baby quest